Chemical modification of biocompatible synthetic and natural shell-building polymers was performed to allow creation of multi-functional core-shell nanocapsules with desired stimuli response and release profiles of skin-care actives. Densely crosslinked capsules loaded with phase change materials with ‘no release’ profile and improved graft-ability to textiles were developed for thermal comfort applications, i.e. ‘smart’ first layer garments with improved thermal management and high durability to washing. Capsules with ‘triggered’ release profile containing natural actives were developed for anti-ageing and antimicrobial cosmetic formulations, respectively. Furthermore, ‘targeted’ capsules specifically interacting with and selectively killing the harmful bacteria were developed for application in new antimicrobial products.